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Vitamin A deficiency symptoms

8 signs and symptoms of vitamin A deficiency

While vitamin A deficiency is rare in developed countries, certain people may be at a higher risk. Here are eight signs and symptoms of vitamin A deficiency.

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This article is based on scientific evidence, written by experts, and fact-checked by experts.
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Last updated on August 3, 2022, and last reviewed by an expert on July 29, 2022.

Vitamin A is a fat-soluble vitamin important for many bodily functions, including proper vision, a robust immune system, reproduction, and good skin health.

There are two types of vitamin A found in foods: preformed vitamin A and provitamin A.

Preformed vitamin A is also known as retinol and is commonly found in meat, fish, eggs, and dairy products.

On the other hand, the body converts carotenoids in plant foods, such as red, green, yellow, and orange fruits and vegetables, into vitamin A.

While deficiency is rare in developed countries, many people in developing countries do not get enough vitamin A.

Those at the highest risk of deficiency are pregnant women, breastfeeding mothers, infants, and children. Cystic fibrosis and chronic diarrhea may also increase your risk of deficiency.

Here are eight signs and symptoms of vitamin A deficiency.

1. Dry skin

Vitamin A is necessary for the creation and repair of skin cells. It also helps fight inflammation due to specific skin issues.

Not getting enough vitamin A may lead to developing eczema and other skin problems.

Eczema is a condition that causes dry, itchy, and inflamed skin. Several clinical studies have shown alitretinoin, a prescription medication with vitamin A activity, to be effective in treating eczema.

In one 12-week study, people with chronic eczema who took 10–40 mg of alitretinoin per day experienced up to a 53% reduction in their symptoms.

Remember that dry skin can have many causes, but chronic vitamin A deficiency may be the reason.

Summary: Vitamin A is essential in skin repair and helps fight inflammation. A deficiency in this nutrient can lead to inflammatory skin conditions.

2. Dry eyes

Eye problems are some of the most well-known issues related to vitamin A deficiency.

In extreme cases, insufficient vitamin A can lead to blindness or dying corneas, characterized by marks called Bitot’s spots.

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Dry eyes, or the inability to produce tears, are one of the first signs of vitamin A deficiency.

Young children in India, Africa, and Southeast Asia with diets lacking in vitamin A are most at risk of developing dry eyes.

Supplementing with vitamin A can improve this condition.

One study found that high doses of vitamin A decreased the prevalence of dry eyes by 63% among infants and children who took supplements for 16 months.

Summary: Vitamin A deficiency can lead to dry eyes, blindness, or dying corneas, also known as Bitot’s spots. One of the first signs of deficiency is often an inability to produce tears.

3. Night blindness

Severe vitamin A deficiency can lead to night blindness.

Several observational studies have reported a high prevalence of night blindness in developing nations.

Due to this problem, health professionals have worked to improve vitamin A levels in people at risk of night blindness.

In one study, women with night blindness were given vitamin A as food or supplements. Both forms of vitamin A improved the condition. The women’s ability to adapt to darkness increased by over 50% over six weeks of treatment.

Summary: Getting adequate amounts of vitamin A is crucial for eye health. Some of the first signs of vitamin A deficiency are dry eyes and night blindness.

4. Infertility and trouble conceiving

Vitamin A is necessary for reproduction in both men and women and proper development in babies.

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If you are having trouble getting pregnant, a lack of vitamin A may be one of the reasons why. Vitamin A deficiency can lead to infertility in both men and women.

Studies show that female rats with vitamin A deficiency have difficulty getting pregnant and may have embryos with birth defects.

Other research suggests that infertile men may have a greater need for antioxidants due to higher levels of oxidative stress in their bodies. Vitamin A is one of the nutrients that act as an antioxidant in the body.

Vitamin A deficiency is also related to miscarriages.

A study that analyzed the blood levels of different nutrients in women who had recurrent miscarriages found that they had low levels of vitamin A.

Summary: Both men and women who do not get adequate vitamin A can have fertility issues. Low vitamin A in parents may also lead to miscarriages or birth defects.

5. Delayed growth

Children who do not get enough vitamin A may experience stunted growth. This is because vitamin A is necessary for the proper development of the human body.

Several studies have shown that vitamin A supplements can improve growth alone or with other nutrients. Most of these studies were conducted on children in developing nations.

A study on over 1,000 children in Indonesia found that those with vitamin A deficiency who took high-dose supplements over four months grew 0.15 inches (0.39 cm) more than children who took a placebo.

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However, a review of studies found that supplementing with vitamin A and other nutrients may have a greater impact on growth than supplementing with vitamin A alone.

For example, children with stunted growth in South Africa who received multiple vitamins and minerals had length-for-age scores that were half a point better than those who received only vitamin A.

Summary: Vitamin A deficiency can cause stunted growth in children. Supplementing with vitamin A and other nutrients may improve growth more than supplementing with vitamin A alone.

6. Throat and chest infections

Frequent infections, especially in the throat or chest, may indicate vitamin A deficiency.

Vitamin A supplements may help with respiratory tract infections, but research results are mixed.

A study in Ecuador showed that underweight children who took 10,000 IU of vitamin A per week had fewer respiratory infections than those who received a placebo.

On the other hand, a review of studies on children found that vitamin A supplements may increase the risk of developing throat and chest infections by 8%.

The authors suggested that supplements should only be given to those with true deficiency.

Furthermore, according to one study on elderly people, high blood levels of the provitamin A carotenoid beta-carotene may protect against respiratory infections.

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Summary: Vitamin A supplements may protect underweight children from infections but increase the risk of infection in other groups. Adults with high blood levels of vitamin A may experience fewer throat and chest infections.

7. Poor wound healing

Wounds that do not heal well after injury or surgery may be linked to low vitamin A levels.

This is because vitamin A promotes the creation of collagen, an important component of healthy skin. Research suggests that both oral and topical vitamin A can strengthen skin.

A study in rats found that oral vitamin A improved collagen production. The vitamin had this effect even though the rats were taking steroids, which can inhibit wound healing.

Additional research in rats found that treating skin with topical vitamin A appeared to prevent wounds associated with diabetes.

Research in humans shows similar results. Elderly men who treated wounds with topical vitamin A had a 50% reduction in the size of their wounds compared to men who did not use the cream.

Summary: Oral and topical forms of vitamin A can promote wound healing, especially in populations that are prone to wounds.

8. Acne

Since vitamin A promotes skin development and fights inflammation, it may help prevent or treat acne.

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Multiple studies have linked low vitamin A levels to the presence of acne.

In one study in 200 adults, vitamin A levels in those with acne were over 80 mcg lower than in those without the condition.

Topical and oral vitamin A may treat acne. Research shows that creams containing vitamin A can reduce the number of acne lesions by 50%.

The most well-known form of oral vitamin A used to treat acne is isotretinoin or Accutane. This medication can treat acne but may have several side effects, including mood changes and birth defects.

Summary: Acne has been associated with low vitamin A levels. Both oral and topical forms of vitamin A are often effective at treating acne but may have unwanted side effects.

Dangers of too much vitamin A

Vitamin A is valuable to overall health. However, too much of it can be dangerous.

Hypervitaminosis A, or vitamin A toxicity, typically results from taking high-dose supplements over long periods. People rarely get too much vitamin A from diet alone.

Excess vitamin A is stored in the liver and can lead to toxicity and problematic symptoms, such as vision changes, swelling of the bones, dry and rough skin, mouth ulcers, and confusion.

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Pregnant women should be especially careful not to consume too much vitamin A to prevent possible birth defects.

Always check with your healthcare provider before starting vitamin A supplements.

People with certain health conditions may need a higher amount of vitamin A. However, most healthy adults need 700–900 mcg per day. Women who are nursing need more, while children need less.

Summary: Vitamin A toxicity usually results from taking too much of the vitamin in supplement form. It can cause serious issues, including vision changes, mouth ulcers, confusion, and birth defects.

Summary

Vitamin A deficiency is prevalent in developing nations but rare in America and other developed nations.

Too little vitamin A can lead to inflamed skin, night blindness, infertility, delayed growth, and respiratory infections.

People with wounds and acne may have lower blood levels of vitamin A and benefit from treatment with higher doses of the vitamin.

Vitamin A is found in meat, dairy, and eggs, as well as red, orange, yellow, and green plant foods. To ensure you get enough vitamin A, eat a variety of these foods.

Talk to your doctor or healthcare provider if you suspect you have a vitamin A deficiency. With the right foods and supplements, fixing a deficiency can be simple.

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